--- a/content/base/test/mochitest.ini
+++ b/content/base/test/mochitest.ini
@@ -286,16 +286,17 @@ skip-if = (buildapp == 'b2g' && toolkit 
 [test_bug338583.html]
 skip-if = buildapp == 'b2g' || toolkit == 'android' # b2g(https not working, bug 907770) b2g-debug(https not working, bug 907770) b2g-desktop(43 total - bug 901343, specialpowers.wrap issue createsystemxhr)
 [test_bug338679.html]
 [test_bug339494.html]
 [test_bug339494.xhtml]
 [test_bug340571.html]
 [test_bug343596.html]
 [test_bug345339.html]
+skip-if = e10s # Bug 1081453 - shutdown leaks with e10s and WebIDL dom::File
 [test_bug346485.html]
 [test_bug352728.html]
 [test_bug352728.xhtml]
 [test_bug353334.html]
 [test_bug355026.html]
 [test_bug357450.html]
 [test_bug357450.js]
 [test_bug357450.xhtml]