--- a/browser/components/originattributes/test/browser/browser.ini
+++ b/browser/components/originattributes/test/browser/browser.ini
@@ -73,17 +73,16 @@ skip-if = verify
 [browser_favicon_userContextId.js]
 [browser_firstPartyIsolation.js]
 skip-if = debug #Bug 1345346
 [browser_firstPartyIsolation_about_newtab.js]
 [browser_firstPartyIsolation_aboutPages.js]
 [browser_firstPartyIsolation_blobURI.js]
 [browser_firstPartyIsolation_js_uri.js]
 [browser_firstPartyIsolation_saveAs.js]
-skip-if = fission
 [browser_localStorageIsolation.js]
 [browser_blobURLIsolation.js]
 skip-if = (verify && debug && (os == 'win'))
 [browser_imageCacheIsolation.js]
 [browser_sharedworker.js]
 [browser_httpauth.js]
 [browser_clientAuth.js]
 skip-if = verify

--- a/browser/components/originattributes/test/browser/browser_firstPartyIsolation_saveAs.js
+++ b/browser/components/originattributes/test/browser/browser_firstPartyIsolation_saveAs.js
@@ -118,50 +118,65 @@ async function doCommandForFrameType() {
   frameMenuPopup.openPopup();
   await frameMenuPopupPromise;
 
   info("Triggering the save process.");
   let saveFrameCommand = contextMenu.querySelector("#context-saveframe");
   saveFrameCommand.doCommand();
 }
 
+add_task(async function test_setup() {
+  // Make sure SearchService is ready for it to be called.
+  await Services.search.init();
+});
+
 add_task(async function testContextMenuSaveAs() {
   const TEST_DATA = [
     { type: "link", path: TEST_PATH, target: "#link1" },
     { type: "video", path: TEST_PATH_VIDEO, target: "#video1" },
     { type: "image", path: TEST_PATH_IMAGE, target: "#image1" },
     { type: "page", path: TEST_PATH_PAGE, target: "body" },
     {
       type: "frame",
       path: TEST_PATH_FRAME,
-      target: "#frame1",
+      target: "body",
       doCommandFunc: doCommandForFrameType,
     },
   ];
 
   for (const data of TEST_DATA) {
     info(`Open a new tab for testing "Save ${data.type} as" in context menu.`);
     let tab = await BrowserTestUtils.openNewForegroundTab(
       gBrowser,
       `${TEST_ORIGIN}${TEST_PATH}?${data.type}=1`
     );
 
     let popupShownPromise = BrowserTestUtils.waitForEvent(
       document,
       "popupshown"
     );
 
+    let browser = gBrowser.selectedBrowser;
+
+    if (data.type === "frame") {
+      browser = await SpecialPowers.spawn(
+        tab.linkedBrowser,
+        [],
+        () => content.document.getElementById("frame1").browsingContext
+      );
+    }
+
     info("Open the context menu.");
     await BrowserTestUtils.synthesizeMouseAtCenter(
       data.target,
       {
         type: "contextmenu",
         button: 2,
       },
-      gBrowser.selectedBrowser
+      browser
     );
 
     await popupShownPromise;
 
     let transferCompletePromise = createPromiseForTransferComplete();
     let observerPromise = createPromiseForObservingChannel(
       data.path,
       TEST_FIRST_PARTY