--- a/build/gecko_templates.mozbuild
+++ b/build/gecko_templates.mozbuild
@@ -20,17 +20,17 @@ def GeckoBinary(linkage='dependent', msv
     `msvcrt` indicates which Microsoft Visual Studio CRT, for Windows build,
     ought to be linked: 'static' or 'dynamic'.
 
     `mozglue` indicates whether to link against the mozglue library, and if
     so, what linkage to apply. Valid values are None (mozglue not linked),
     'program' (mozglue linked to an executable program), or 'library' (mozglue
     linked to a shared library).
     '''
-    if msvcrt == 'dynamic' or CONFIG['OS_ARCH'] != 'WINNT':
+    if msvcrt == 'dynamic' or CONFIG['OS_ARCH'] != 'WINNT' or CONFIG['MOZ_ASAN']:
         xpcomglue = 'xpcomglue'
     elif msvcrt == 'static':
         USE_STATIC_LIBS = True
         xpcomglue = 'xpcomglue_staticruntime'
         if not CONFIG['GNU_CC']:
             mozglue = None
             if linkage == 'dependent':
                 USE_LIBS += [

--- a/config/config.mk
+++ b/config/config.mk
@@ -376,16 +376,22 @@ CXXFLAGS += $(WARNINGS_AS_ERRORS)
 CFLAGS   += $(WARNINGS_AS_ERRORS)
 endif # ALLOW_COMPILER_WARNINGS
 
 ifeq ($(OS_ARCH)_$(GNU_CC),WINNT_)
 #// Currently, unless USE_STATIC_LIBS is defined, the multithreaded
 #// DLL version of the RTL is used...
 #//
 #//------------------------------------------------------------------------
+ifdef MOZ_ASAN
+# ASAN-instrumented code tries to link against the dynamic CRT, which can't be
+# used in the same link as the static CRT.
+USE_STATIC_LIBS=
+endif # MOZ_ASAN
+
 ifdef USE_STATIC_LIBS
 RTL_FLAGS=-MT          # Statically linked multithreaded RTL
 ifdef MOZ_DEBUG
 ifndef MOZ_NO_DEBUG_RTL
 RTL_FLAGS=-MTd         # Statically linked multithreaded MSVC4.0 debug RTL
 endif
 endif # MOZ_DEBUG
 

--- a/ipc/app/moz.build
+++ b/ipc/app/moz.build
@@ -12,17 +12,17 @@ if CONFIG['MOZ_WIDGET_TOOLKIT'] == 'andr
         'MozillaRuntimeMainAndroid.cpp',
     ]
 
     DIRS += ['pie']
 else:
     kwargs = {
         'linkage': None,
     }
-    if CONFIG['MOZ_SANDBOX'] and CONFIG['OS_ARCH'] == 'WINNT':
+    if CONFIG['MOZ_SANDBOX'] and CONFIG['OS_ARCH'] == 'WINNT' and not CONFIG['MOZ_ASAN']:
         kwargs['msvcrt'] = 'static'
         if not CONFIG['GNU_CC']:
             USE_LIBS += [
                 'mozalloc_staticruntime',
             ]
     GeckoProgram(CONFIG['MOZ_CHILD_PROCESS_NAME'], **kwargs)
 
     SOURCES += [
@@ -50,19 +50,27 @@ if CONFIG['OS_TARGET'] != 'Android':
 if CONFIG['MOZ_SANDBOX'] and CONFIG['OS_ARCH'] == 'WINNT':
     # For sandbox includes and the include dependencies those have
     LOCAL_INCLUDES += [
         '/security/sandbox/chromium',
         '/security/sandbox/chromium-shim',
     ]
     USE_LIBS += [
         'rlz',
-        'sandbox_staticruntime_s',
     ]
 
+    if CONFIG['MOZ_ASAN']:
+        USE_LIBS += [
+            'sandbox_s',
+        ]
+    else:
+        USE_LIBS += [
+            'sandbox_staticruntime_s',
+        ]
+
     # clang-cl can't deal with this delay-load due to bug 1188045
     # (also filed as https://llvm.org/bugs/show_bug.cgi?id=24291)
     if not CONFIG['CLANG_CL']:
         DELAYLOAD_DLLS += [
             'nss3.dll',
             'xul.dll'
         ]