--- a/layout/base/PresShell.cpp
+++ b/layout/base/PresShell.cpp
@@ -7391,17 +7391,21 @@ PresShell::HandleEvent(nsIFrame* aFrame,
     nsCOMPtr<nsPIDOMWindowOuter> window = GetFocusedDOMWindowInOurWindow();
     nsCOMPtr<nsIDocument> retargetEventDoc =
       window ? window->GetExtantDoc() : nullptr;
     nsCOMPtr<nsIPresShell> presShell =
       retargetEventDoc ? retargetEventDoc->GetShell() : nullptr;
 
     RefPtr<AccessibleCaretEventHub> eventHub =
       presShell ? presShell->GetAccessibleCaretEventHub() : nullptr;
-    if (eventHub) {
+    if (eventHub && *aEventStatus != nsEventStatus_eConsumeNoDefault) {
+      // Don't dispatch event to AccessibleCaretEventHub when the event status
+      // is nsEventStatus_eConsumeNoDefault. This might be happened when content
+      // preventDefault on the pointer events. In such case, we also call
+      // preventDefault on mouse events to stop default behaviors.
       *aEventStatus = eventHub->HandleEvent(aEvent);
       if (*aEventStatus == nsEventStatus_eConsumeNoDefault) {
         // If the event is consumed, cancel APZC panning by setting
         // mMultipleActionsPrevented.
         aEvent->mFlags.mMultipleActionsPrevented = true;
         return NS_OK;
       }
     }